Dichloromethane → 5-(7-(piperidin-4-yloxy)-quinazolin-2-ylamino]-1H-benzo[d]imidazol-2(3H)-one

HRID 302749Notes

Reaction equation

HRID 302749 reaction equation
[Cl:43][CH2:44][Cl:45].[F:36][C:37]([F:38])([F:39])[C:40]([OH:41])=[O:42].[O:1]=[c:2]1[nH:3][c:4]2[c:5]([nH:6]1)[cH:7][cH:8][c:9]([NH:11][c:12]1[n:13][c:14]3[cH:15][c:16]([O:22][CH:23]4[CH2:24][CH2:25][N:26]([C:29]([O:30][C:31]([CH3:32])([CH3:33])[CH3:34])=[O:35])[CH2:27][CH2:28]4)[cH:17][cH:18][c:19]3[cH:20][n:21]1)[cH:10]2>>[O:1]=[c:2]1[nH:3][c:4]2[c:5]([nH:6]1)[cH:7][cH:8][c:9]([NH:11][c:12]1[n:13][c:14]3[cH:15][c:16]([O:22][CH:23]4[CH2:24][CH2:25][NH:26][CH2:27][CH2:28]4)[cH:17][cH:18][c:19]3[cH:20][n:21]1)[cH:10]2

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 67102611tert-butyl 4-(2-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-ylamino) quinazolin-7-yloxy)piperidine-1-carboxylate

Product 1

HCID 591992475-(7-(piperidin-4-yloxy)-quinazolin-2-ylamino]-1H-benzo[d]imidazol-2(3H)-one

Sources & evidence

ORD record
ord-79c20418cfb84270be416d7a4920f09b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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