4-(4-Bromo-thiophen-2-yl)-1-(1-phenyl-ethyl)-pyrrolidine-3-carboxylic acid methyl ester → HCID 67317858, compound

HRID 30292Notes

Reaction equation

HRID 30292 reaction equation
C[O:2][C:3]([CH:5]1[CH:9]([C:10]2[S:11][CH:12]=[C:13]([Br:15])[CH:14]=2)[CH2:8][N:7]([CH:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH3:17])[CH2:6]1)=[O:4].C1NCC2C1CC1C(C#N)=CSC=12>>[Br:15][C:13]1[CH:14]=[C:10]([CH:9]2[CH2:8][N:7]([CH:16]([C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=3)[CH3:17])[CH2:6][CH:5]2[C:3]([OH:4])=[O:2])[S:11][CH:12]=1

Participants

3

Reactant 2

HCID 672048964-(4-Bromo-thiophen-2-yl)-1-(1-phenyl-ethyl)-pyrrolidine-3-carboxylic acid methyl esterHCID 683017591,2,3,3a,7,7a-Hexahydro-4-thia-2-aza-cyclopenta[alpha]pentalene-6-carbonitrile

Product 1

HCID 67317858HCID 67317858, compoundYield 100%

Procedure

The product of step b), diastereomer 1 (15 g, 0.038 mol) was treated by the method outlined in Example 34, step c) to afford the subtitle compound (14.7 g, yield: 100%). MS calculated for C17H18BrNO2S+H: 380, observed 380 and 383.

Sources & evidence

ORD record
ord-838da65c46e447e785cac488f6d87328
Source dataset
uspto-grants-2008_09
Patent number
US07423056B2

Reaction notes

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