Sodium ion → 3-Bromo-6-(2-fluoro-phenyl)-pyridazine

HRID 303065Notes

Reaction equation

HRID 303065 reaction equation
[Br:1][c:2]1[n:3][n:4][c:5]([Br:8])[cH:6][cH:7]1.[CH3:25][O:26][CH2:27][CH2:28][O:29][CH3:30].[F:9][c:10]1[c:11]([B:16]([OH:17])[OH:18])[cH:12][cH:13][cH:14][cH:15]1.[Na+:19].[Na+:20].[O-:21][C:22](=[O:23])[O-:24].[cH:31]1[cH:32][cH:33][c:34]([P:35]([Pd:36]([P:37]([c:38]2[cH:39][cH:40][cH:41][cH:42][cH:43]2)([c:44]2[cH:45][cH:46][cH:47][cH:48][cH:49]2)[c:50]2[cH:51][cH:52][cH:53][cH:54][cH:55]2)([P:56]([c:57]2[cH:58][cH:59][cH:60][cH:61][cH:62]2)([c:63]2[cH:64][cH:65][cH:66][cH:67][cH:68]2)[c:69]2[cH:70][cH:71][cH:72][cH:73][cH:74]2)[P:75]([c:76]2[cH:77][cH:78][cH:79][cH:80][cH:81]2)([c:82]2[cH:83][cH:84][cH:85][cH:86][cH:87]2)[c:88]2[cH:89][cH:90][cH:91][cH:92][cH:93]2)([c:94]2[cH:95][cH:96][cH:97][cH:98][cH:99]2)[c:100]2[cH:101][cH:102][cH:103][cH:104][cH:105]2)[cH:106][cH:107]1>>[Br:1][c:2]1[n:3][n:4][c:5](-[c:11]2[c:10]([F:9])[cH:15][cH:14][cH:13][cH:12]2)[cH:6][cH:7]1

Participants

7

Reactant 6

HCID 923Sodium ion2×HCID 80711,2-DimethoxyethaneHCID 19660Carbonate IonHCID 2488523,6-DibromopyridazineHCID 27343542-Fluorophenylboronic acidHCID 178420554HCID 178420554, compound

Product 1

HCID 457878323-Bromo-6-(2-fluoro-phenyl)-pyridazine

Sources & evidence

ORD record
ord-7b009d3a33134eab8b327bd211c157d4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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