Dichloromethane → 2-Chloro-4-[4-(2-hydroxy-4-methylpentanoyl)piperazin-1-yl]quinazoline-7-carboxylic acid

HRID 303304Notes

Reaction equation

HRID 303304 reaction equation
[CH3:30][CH2:31][N:32]([CH2:33][CH3:34])[CH2:35][CH3:36].[Cl:1][c:2]1[n:3][c:4]2[cH:5][c:6]([C:13](=[O:14])[OH:15])[cH:7][cH:8][c:9]2[c:10]([Cl:12])[n:11]1.[Cl:37][CH2:38][Cl:39].[OH:16][CH:17]([C:18](=[O:19])[N:20]1[CH2:21][CH2:22][NH:23][CH2:24][CH2:25]1)[CH2:26][CH:27]([CH3:28])[CH3:29]>>[Cl:1][c:2]1[n:3][c:4]2[cH:5][c:6]([C:13](=[O:14])[OH:15])[cH:7][cH:8][c:9]2[c:10]([N:23]2[CH2:22][CH2:21][N:20]([C:18]([CH:17]([OH:16])[CH2:26][CH:27]([CH3:28])[CH3:29])=[O:19])[CH2:25][CH2:24]2)[n:11]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 204913512,4-Dichloroquinazoline-7-carboxylic acidHCID 670982582-Hydroxy-4-methyl-1-piperazin-1-yl-pentan-1-one

Product 1

HCID 872684752-Chloro-4-[4-(2-hydroxy-4-methylpentanoyl)piperazin-1-yl]quinazoline-7-carboxylic acid

Sources & evidence

ORD record
ord-ccb4578d16a94798a9447fdfa08ca3cd
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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