Methanol → 5-chloro-2-methyl-6,7-dihydrocyclopenta[e]indazol-8(2H)-one

HRID 303357Notes

Reaction equation

HRID 303357 reaction equation
[CH3:22][OH:23].[CH3:24][O-:25].[Cl:1][c:2]1[c:3]([CH2:16][CH2:17][C:18](=[O:13])[O:20][CH3:12])[c:4]([C:14]([O:15][CH3:19])=[O:21])[c:5]2[cH:6][n:7]([CH3:11])[n:8][c:9]2[cH:10]1.[Na+:26].[Na+:33].[O:34]1[CH2:35][CH2:36][CH2:37][CH2:38]1.[OH-:32].[S:27](=[O:28])(=[O:29])([OH:30])[OH:31]>>[Cl:1][c:2]1[c:3]2[c:4]([c:5]3[cH:6][n:7]([CH3:11])[n:8][c:9]3[cH:10]1)[C:18](=[O:20])[CH2:17][CH2:16]2

Participants

8

Reactant 7

HCID 887MethanolHCID 923Sodium ion2×HCID 961HydroxideHCID 1118Sulfuric AcidHCID 8028TetrahydrofuranHCID 3826051MethoxideHCID 59145878methyl 6-chloro-5-(3-methoxy-3-oxopropyl)-2-methyl-2H-indazole-4-carboxylate

Product 1

HCID 591459335-chloro-2-methyl-6,7-dihydrocyclopenta[e]indazol-8(2H)-one

Sources & evidence

ORD record
ord-15587a9ce7304a24b791e8f4af5d4662
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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