HRID3035

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID64774

Pyridinium fluoride

C5H6FN

结构：CCCCC[C@@H](/C=C/[C@@H]1C(SCCCCCC(=O)OC)=C(OC(=O)[C@H](Cc2ccccc2)NC(=O)OCc2ccccc2)C[C@H]1O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C

HCID22883810

未命名化合物

PRODUCTS

生成物

结构：CCCCC[C@H](O)/C=C/[C@@H]1C(SCCCCCC(=O)OC)=C(OC(=O)[C@H](Cc2ccccc2)NC(=O)OCc2ccccc2)C[C@H]1O

HCID22883811

未命名化合物

收率 51%

PROCEDURE

实验过程

Using as the material and reagent a hydrogen fluoride-pyridine solution (0.3 ml) and methyl(11R,12S,13E,15S)-9-(N-benzyloxycarbonylphenylalanyloxy)-11,15-bis(tert-butyldimethylsiloxy)-7-thiaprosta-8,13-dienoate (140 mg), methyl(11R,12S,13E,15S)-9-(N-benzyloxycarbonylphenylalanyloxy)-11,15-dihydroxy-7-thiaprosta-8,13-dienoate (53 mg, 51%) was obtained.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d5c0f98feabe41e293e98aa397fcf97a
来源数据集: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05731452
来源说明: uspto-grants-1998_03

反应 SMILES

N1C=CC=CC=1.F.[CH3:8][O:9][C:10](=[O:68])[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][S:16][C:17]1[C@@H:21](/[CH:22]=[CH:23]/[C@@H:24]([O:30][Si](C(C)(C)C)(C)C)[CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])[C@H:20]([O:38][Si](C(C)(C)C)(C)C)[CH2:19][C:18]=1[O:46][C:47](=[O:67])[C@H:48]([CH2:60][C:61]1[CH:66]=[CH:65][CH:64]=[CH:63][CH:62]=1)[NH:49][C:50]([O:52][CH2:53][C:54]1[CH:59]=[CH:58][CH:57]=[CH:56][CH:55]=1)=[O:51]>>[CH3:8][O:9][C:10](=[O:68])[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][S:16][C:17]1[C@@H:21](/[CH:22]=[CH:23]/[C@@H:24]([OH:30])[CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])[C@H:20]([OH:38])[CH2:19][C:18]=1[O:46][C:47](=[O:67])[C@H:48]([CH2:60][C:61]1[CH:66]=[CH:65][CH:64]=[CH:63][CH:62]=1)[NH:49][C:50]([O:52][CH2:53][C:54]1[CH:59]=[CH:58][CH:57]=[CH:56][CH:55]=1)=[O:51]