Chloride → Morpholine-4-carboxylic acid 1-[2-(4-fluorophenyl)acetyl]-2-(2-phenoxypyrimidine-4-carbonyl)-pyrazolidin-4-yl ester

HRID 303583Notes

Reaction equation

HRID 303583 reaction equation
[Cl-:43].[Cl:44][CH2:45][Cl:46].[F:1][c:2]1[cH:3][cH:4][c:5]([CH2:8][C:9](=[O:10])[N:11]2[NH:12][CH2:13][CH:14]([O:16][C:17](=[O:18])[N:19]3[CH2:20][CH2:21][O:22][CH2:23][CH2:24]3)[CH2:15]2)[cH:6][cH:7]1.[Na+:42].[O:25]([c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1)[c:32]1[n:33][cH:34][cH:35][c:36]([C:38](=[O:39])[Cl:40])[n:37]1.[OH-:41]>>[F:1][c:2]1[cH:3][cH:4][c:5]([CH2:8][C:9](=[O:10])[N:11]2[N:12]([C:38]([c:36]3[cH:35][cH:34][n:33][c:32]([O:25][c:26]4[cH:27][cH:28][cH:29][cH:30][cH:31]4)[n:37]3)=[O:39])[CH2:13][CH:14]([O:16][C:17](=[O:18])[N:19]3[CH2:20][CH2:21][O:22][CH2:23][CH2:24]3)[CH2:15]2)[cH:6][cH:7]1

Participants

7

Reactant 6

HCID 312ChlorideHCID 923Sodium ionHCID 961HydroxideHCID 6344DichloromethaneHCID 129701582-Phenoxypyrimidine-4-carbonyl chlorideHCID 20724737Morpholine-4-carboxylic acid 1-[2-(4-fluorophenyl)acetyl]-pyrazolidin-4-yl ester

Product 1

HCID 20724735Morpholine-4-carboxylic acid 1-[2-(4-fluorophenyl)acetyl]-2-(2-phenoxypyrimidine-4-carbonyl)-pyrazolidin-4-yl ester

Sources & evidence

ORD record
ord-2859ab1994514a5f8c3a0279ad261c34
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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