Tetrahydrofuran → (9-((4-(2-Hydroxyethyl)thiophen-2-yl)methyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(5-methylthiophen-2-yl)methanone

HRID 303780Notes

Reaction equation

HRID 303780 reaction equation
[C:19]([Si:20]([CH3:21])([CH3:22])[O:24][CH2:25][CH2:26][c:27]1[cH:28][c:29]([CH2:32][N:33]2[CH2:34][CH2:35][C:36]3([CH2:37][N:38]([C:42](=[O:43])[c:44]4[s:45][c:46]([CH3:49])[cH:47][cH:48]4)[CH2:39][CH2:40][O:41]3)[CH2:50][CH2:51]2)[s:30][cH:31]1)([CH3:23])([CH3:52])[CH3:53].[CH3:2][CH2:3][CH2:4][CH2:5][N+:6]([CH2:7][CH2:8][CH2:9][CH3:10])([CH2:11][CH2:12][CH2:13][CH3:14])[CH2:15][CH2:16][CH2:17][CH3:18].[F-:1].[O:54]1[CH2:55][CH2:56][CH2:57][CH2:58]1>>[OH:24][CH2:25][CH2:26][c:27]1[cH:28][c:29]([CH2:32][N:33]2[CH2:34][CH2:35][C:36]3([CH2:37][N:38]([C:42](=[O:43])[c:44]4[s:45][c:46]([CH3:49])[cH:47][cH:48]4)[CH2:39][CH2:40][O:41]3)[CH2:50][CH2:51]2)[s:30][cH:31]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 16028TetrabutylammoniumHCID 28179Fluoride IonHCID 57989318(9-((4-(2-(tert-Butyldimethylsilyloxy)ethyl)thiophen-2-yl)methyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(5-methylthiophen-2-yl)methanone

Product 1

HCID 57989018(9-((4-(2-Hydroxyethyl)thiophen-2-yl)methyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(5-methylthiophen-2-yl)methanone

Sources & evidence

ORD record
ord-859fcda986984ec2834ba468f9b7c72e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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