Dichloromethane → 4-(3,4-Dichloro-phenoxy)-[1,4']bipiperidine

HRID 304050Notes

Reaction equation

HRID 304050 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][CH:11]([N:14]2[CH2:15][CH2:16][CH:17]([O:20][c:21]3[cH:22][c:23]([Cl:28])[c:24]([Cl:27])[cH:25][cH:26]3)[CH2:18][CH2:19]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:36][CH2:37][Cl:38].[OH:29][C:30]([C:31]([F:32])([F:33])[F:34])=[O:35]>>[NH:8]1[CH2:9][CH2:10][CH:11]([N:14]2[CH2:15][CH2:16][CH:17]([O:20][c:21]3[cH:22][c:23]([Cl:28])[c:24]([Cl:27])[cH:25][cH:26]3)[CH2:18][CH2:19]2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 112125444-(3,4-Dichlorophenoxy)-[1,4']bipiperidinyl-1'-carboxylic acid tert-butyl ester

Product 1

HCID 223974344-(3,4-Dichloro-phenoxy)-[1,4']bipiperidine

Sources & evidence

ORD record
ord-3b6df7e243d346c8818735660ddc5b99
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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