HRID30413

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID4184869

tert-Butyl 4-[(methanesulfonyl)oxy]piperidine-1-carboxylate

C11H21NO5S

2 次

结构：C=Cc1ccc(C=C)cc1.C=Cc1ccccc1.CCN(CC)P1(=NC(C)(C)C)N(C)CCCN1Cc1ccccc1

HCID16216994

未命名化合物

结构：CC(C)(C)OC(=O)N1CCC(Oc2nn(-c3ccc(Cl)cc3)c3ccccc23)CC1

HCID68530176

未命名化合物

HCID178518865

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N1CCC(Oc2nn(-c3ccccc3F)c3cccc(F)c23)CC1

HCID68532836

未命名化合物

收率 51%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

4-[4-Fluoro-1-(2-fluoro-phenyl)-1H-indazol-3-yloxy]-piperidine-1-carboxylic acid tert-butyl ester (Intermediate 46) was prepared as described above for Intermediate 42 using Intermediate 45 (300 mg, 1.218 mmol), PS-BEMP resin (1.108 g) and 4-methanesulfonyloxy-piperidine-1-carboxylic acid tert-butyl ester (Intermediate 2) (374 mg, 1.34 mmol) in DMF (10 ml) to afford 265 mg (51%) of Intermediate 46 as a yellow oil. MS (M+1)=430.2.

WORKUP

后处理

custom4-[4-Fluoro-1-(2-fluoro-phenyl)-1H-indazol-3-yloxy]-piperidine-1-carboxylic acid tert-butyl ester (Intermediate 46) was prepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-150fdb8a77df4999909115a7edd9ba62
来源数据集: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07423054B2
来源说明: uspto-grants-2008_09

反应 SMILES

[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11](OC2C3C(=CC=CC=3)N(C3C=CC(Cl)=CC=3)N=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[F:31][C:32]1[CH:40]=[CH:39][CH:38]=[C:37]2[C:33]=1[C:34]([OH:48])=[N:35][N:36]2[C:41]1[CH:46]=[CH:45][CH:44]=[CH:43][C:42]=1[F:47].CCN(P1(N(CC2C=CC=CC=2)CCCN1C)=NC(C)(C)C)CC.C=CC1C=CC=CC=1.C=CC1C=CC(C=C)=CC=1.C(OC(N1CCC(OS(C)(=O)=O)CC1)=O)(C)(C)C>CN(C=O)C>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([O:48][C:34]2[C:33]3[C:37](=[CH:38][CH:39]=[CH:40][C:32]=3[F:31])[N:36]([C:41]3[CH:46]=[CH:45][CH:44]=[CH:43][C:42]=3[F:47])[N:35]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]