Acetic Acid → 1-(diphenylmethyl)-3-(4-fluoro-2-hydroxy-5-methoxyphenyl)-1,3-dihydro-2H-indol-2-one

HRID 304158Notes

Reaction equation

HRID 304158 reaction equation
[CH3:35][CH2:36][N:37]([CH2:38][CH3:39])[CH2:40][CH3:41].[CH3:46][C:47](=[O:48])[OH:49].[Cl:50][CH:51]([Cl:52])[CH3:53].[S:42]([Cl:43])([Cl:44])=[O:45].[Zn:54].[c:1]1([CH:7]([N:8]2[C:9](=[O:28])[C:10]([OH:17])([c:18]3[c:19]([OH:27])[cH:20][c:21]([F:26])[c:22]([O:24][CH3:25])[cH:23]3)[c:11]3[cH:12][cH:13][cH:14][cH:15][c:16]32)[c:29]2[cH:30][cH:31][cH:32][cH:33][cH:34]2)[cH:2][cH:3][cH:4][cH:5][cH:6]1>>[c:1]1([CH:7]([N:8]2[C:9](=[O:28])[CH:10]([c:18]3[c:19]([OH:27])[cH:20][c:21]([F:26])[c:22]([O:24][CH3:25])[cH:23]3)[c:11]3[cH:12][cH:13][cH:14][cH:15][c:16]32)[c:29]2[cH:30][cH:31][cH:32][cH:33][cH:34]2)[cH:2][cH:3][cH:4][cH:5][cH:6]1

Participants

7

Reactant 6

HCID 176Acetic AcidHCID 63651,1-DichloroethaneHCID 8471TriethylamineHCID 23994ZincHCID 24386Thionyl ChlorideHCID 67357402HCID 67357402, compound

Product 1

HCID 673773961-(diphenylmethyl)-3-(4-fluoro-2-hydroxy-5-methoxyphenyl)-1,3-dihydro-2H-indol-2-one

Sources & evidence

ORD record
ord-c937fc9541e24ceeb13d5734efe2f0b4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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