反应详情

Benzene 1,3 dicarbaldehyde (1 eq) is dissolved in toluene, and diethylmalonate (1 eq) is added, followed by piperidine (0.1 eq) and AcOH (0.1 eq). The flask is equipped with a Dean Stark trap and the reaction mixture is refluxed overnight. The reaction mixture is cooled down to room temperature, washed with water, 2% aq HCl, sat. aq NaHCO3, brine, and dried. The solvent is evaporated under reduced pressure and the product 32 is isolated by column chromatography on silicagel.

1. customThe flask is equipped with a Dean Stark trap
2. temperaturethe reaction mixture is refluxed overnight
3. washwashed with water, 2% aq HCl, sat. aq NaHCO3, brine
4. customdried
5. customThe solvent is evaporated under reduced pressure