Sodium ion → 2-[6-(3,5-difluorophenyl)-3,3-dimethyl-2-oxopiperidin-1-yl]-N-methyl-N-(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)acetamide

HRID 304578Notes

Reaction equation

HRID 304578 reaction equation
[Cl:62][CH2:63][Cl:64].[F:1][c:2]1[cH:3][c:4]([CH:9]2[CH2:10][CH2:11][C:12]([CH3:47])([CH3:48])[C:13](=[O:46])[N:14]2[CH2:15][C:16](=[O:17])[N:18]([c:19]2[cH:20][c:21]3[c:25]([cH:26][cH:27]2)[CH2:24][C:23]2([CH2:22]3)[C:28](=[O:44])[N:29]([CH2:36][O:37][CH2:38][CH2:39][Si:40]([CH3:41])([CH3:42])[CH3:43])[c:30]3[n:31][cH:32][cH:33][cH:34][c:35]32)[CH3:45])[cH:5][c:6]([F:8])[cH:7]1.[F:49][C:50]([F:51])([F:52])[C:53]([OH:54])=[O:55].[NH2:58][CH2:59][CH2:60][NH2:61].[Na+:57].[OH-:56]>>[F:1][c:2]1[cH:3][c:4]([CH:9]2[CH2:10][CH2:11][C:12]([CH3:47])([CH3:48])[C:13](=[O:46])[N:14]2[CH2:15][C:16](=[O:17])[N:18]([c:19]2[cH:20][c:21]3[c:25]([cH:26][cH:27]2)[CH2:24][C:23]2([CH2:22]3)[C:28](=[O:44])[NH:29][c:30]3[n:31][cH:32][cH:33][cH:34][c:35]32)[CH3:45])[cH:5][c:6]([F:8])[cH:7]1

Participants

7

Reactant 6

HCID 923Sodium ionHCID 961HydroxideHCID 3301EthylenediamineHCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 178485777HCID 178485777, compound

Product 1

HCID 579775542-[6-(3,5-difluorophenyl)-3,3-dimethyl-2-oxopiperidin-1-yl]-N-methyl-N-(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)acetamide

Sources & evidence

ORD record
ord-bd17cae76ea14fccb790959d045d756c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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