Piperidine → 2-Bromo-6-piperidin-1-ylmethylpyridine

HRID 30474Notes

Reaction equation

HRID 30474 reaction equation
[Br:1][C:2]1[N:7]=[C:6]([CH:8]=O)[CH:5]=[CH:4][CH:3]=1.[NH:10]1[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1>>[Br:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]([CH2:8][N:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)[N:7]=1

Participants

3

Reactant 2

HCID 8082PiperidineHCID 27570096-Bromopyridine-2-carbaldehyde

Product 1

HCID 137845442-Bromo-6-piperidin-1-ylmethylpyridineYield 83%

Procedure

The title compound was prepared in a manner similar to that described in Example 18, Step C, using 6-bromo-pyridine-2-carbaldehyde (0.406 g, 2.18 mmol) and piperidine (0.186 g, 2.18 mmol). The crude product was purified (SiO2: 0-4% 2 M NH3 in MeOH/DCM) to provide the title compound (0.46 g, 83%).

Workup

  1. customThe title compound was prepared in a manner similar to
  2. customThe crude product was purified (SiO2: 0-4% 2 M NH3 in MeOH/DCM)

Sources & evidence

ORD record
ord-80147ff5faa744f38515986596c0a938
Source dataset
uspto-grants-2008_09
Patent number
US07423147B2

Reaction notes

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