Morpholine → 4-((6-Bromopyridin-2-yl)methyl)morpholine

HRID 30476Notes

Reaction equation

HRID 30476 reaction equation
[Br:1][C:2]1[N:7]=[C:6]([CH:8]=O)[CH:5]=[CH:4][CH:3]=1.[NH:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1>>[Br:1][C:2]1[N:7]=[C:6]([CH2:8][N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)[CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 27570096-Bromopyridine-2-carbaldehyde

Product 1

HCID 234381474-((6-Bromopyridin-2-yl)methyl)morpholineYield 61.4%

Procedure

The title compound was prepared in a manner similar to that described in Example 18, Step C, using 6-bromo-pyridine-2-carbaldehyde (0.415 g, 2.23 mmol) and morpholine (0.195 g, 2.23 mmol). The crude product was purified (SiO2: 0-3% 2 M NH3 in MeOH/DCM) to give the title compound (0.352 g, 61%).

Workup

  1. customThe title compound was prepared in a manner similar to
  2. customThe crude product was purified (SiO2: 0-3% 2 M NH3 in MeOH/DCM)

Sources & evidence

ORD record
ord-fa5bebcc2d7d478e86bde5e4dc353426
Source dataset
uspto-grants-2008_09
Patent number
US07423147B2

Reaction notes

Loading…