Dichloromethane → 2-(3-(4-(1H-indazol-5-ylamino)-7-methoxy-6-(2-methoxyethoxy)-quinazolin-2-yl)phenoxy)-N-isopropylacetamide

HRID 304766Notes

Reaction equation

HRID 304766 reaction equation
[CH:1]([CH3:2])([CH3:3])[NH:4][C:5]([CH2:6][O:7][c:8]1[cH:9][c:10](-[c:14]2[n:15][c:16]3[cH:17][c:18]([O:46][CH3:47])[c:19]([O:41][CH2:42][CH2:43][O:44][CH3:45])[cH:20][c:21]3[c:22]([NH:24][c:25]3[cH:26][c:27]4[cH:28][n:29][n:30]([C:34]([O:35][C:36]([CH3:37])([CH3:38])[CH3:39])=[O:40])[c:31]4[cH:32][cH:33]3)[n:23]2)[cH:11][cH:12][cH:13]1)=[O:48].[Cl:49][CH2:50][Cl:51].[F:52][C:53]([F:54])([F:55])[C:56]([OH:57])=[O:58]>>[CH:1]([CH3:2])([CH3:3])[NH:4][C:5]([CH2:6][O:7][c:8]1[cH:9][c:10](-[c:14]2[n:15][c:16]3[cH:17][c:18]([O:46][CH3:47])[c:19]([O:41][CH2:42][CH2:43][O:44][CH3:45])[cH:20][c:21]3[c:22]([NH:24][c:25]3[cH:26][c:27]4[cH:28][n:29][nH:30][c:31]4[cH:32][cH:33]3)[n:23]2)[cH:11][cH:12][cH:13]1)=[O:48]

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 59361834tert-butyl 5-(2-(3-(2-(isopropylamino)-2-oxoethoxy)phenyl)-7-methoxy-6-(2-methoxyethoxy)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

Product 1

HCID 250120872-(3-(4-(1H-indazol-5-ylamino)-7-methoxy-6-(2-methoxyethoxy)-quinazolin-2-yl)phenoxy)-N-isopropylacetamide

Sources & evidence

ORD record
ord-ffb8e0195d304de9b67c02030ab6fe16
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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