Tetrahydrofuran → tert-Butyl 4-(4-(tert-butoxycarbonylamino)naphthalen-1-yloxy)pyrimidin-2-ylcarbamate
Reaction equation
[C:1]([NH2:2])([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])=[O:8].[C:35](=[O:36])([O-:37])[O-:38].[CH2:41]1[O:42][CH2:43][CH2:44][CH2:45]1.[Cl:9][c:10]1[n:11][cH:12][cH:13][c:14]([O:16][c:17]2[cH:18][cH:19][c:20]([NH:27][C:28]([O:29][C:30]([CH3:31])([CH3:32])[CH3:33])=[O:34])[c:21]3[cH:22][cH:23][cH:24][cH:25][c:26]23)[n:15]1.[Cs+:39].[Cs+:40].[O:48]=[C:49]([CH:50]=[CH:51][c:52]1[cH:53][cH:54][cH:55][cH:56][cH:57]1)[CH:58]=[CH:59][c:60]1[cH:61][cH:62][cH:63][cH:64][cH:65]1.[O:66]=[C:67]([CH:68]=[CH:69][c:70]1[cH:71][cH:72][cH:73][cH:74][cH:75]1)[CH:76]=[CH:77][c:78]1[cH:79][cH:80][cH:81][cH:82][cH:83]1.[O:84]=[C:85]([CH:86]=[CH:87][c:88]1[cH:89][cH:90][cH:91][cH:92][cH:93]1)[CH:94]=[CH:95][c:96]1[cH:97][cH:98][cH:99][cH:100][cH:101]1.[Pd:46].[Pd:47]>>[C:1]([NH:2][c:10]1[n:11][cH:12][cH:13][c:14]([O:16][c:17]2[cH:18][cH:19][c:20]([NH:27][C:28]([O:29][C:30]([CH3:31])([CH3:32])[CH3:33])=[O:34])[c:21]3[cH:22][cH:23][cH:24][cH:25][c:26]23)[n:15]1)([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])=[O:8]Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-416e395488104d54b7c01e39bc66e0af
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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