1-Butanol → Methyl 4-(5-chloro-4-(methylamino)pyrimidin-2-ylamino)-3-(difluoromethoxy)benzoate
Reaction equation
[CH2:33]([OH:34])[CH2:35][CH2:36][CH3:37].[Cl:16][c:17]1[n:18][cH:19][c:20]([Cl:25])[c:21]([NH:23][CH3:24])[n:22]1.[ClH:26].[NH2:1][c:2]1[c:3]([O:12][CH:13]([F:14])[F:15])[cH:4][c:5]([C:6](=[O:7])[O:8][CH3:9])[cH:10][cH:11]1.[O:27]1[CH2:28][CH2:29][O:30][CH2:31][CH2:32]1>>[NH:1]([c:2]1[c:3]([O:12][CH:13]([F:14])[F:15])[cH:4][c:5]([C:6](=[O:7])[O:8][CH3:9])[cH:10][cH:11]1)[c:17]1[n:18][cH:19][c:20]([Cl:25])[c:21]([NH:23][CH3:24])[n:22]1Participants
6
Sources & evidence
- ORD record
- ord-e76cc3d3bbd64c2982e12da01c040628
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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