反应详情

温度

100 °C

A mixture of 1-(3-bromophenyl)butan-1-one (1.0 g, 4.4 mmol) and diglyme (10 mL) was treated with hydrazine (1.49 g, 44 mmol), stirred at 100° C. for 2 h, treated with KOH (1.23 g, 22 mmol), stirred at 150° C. for 6 hours, cooled to room temperature, poured into water and extracted with ethyl ether. The organic extracts were combined, dried over MgSO4 and concentrated under vacuum. Purification of the resultant residue on silica gel (ISCO) using hexanes as the eluting solvent gave 1-bromo-3-butylbenzene as a clear oil (0.81 g, 86% yield).

1. stirringstirred at 150° C. for 6 hours
2. temperaturecooled to room temperature
3. extractionextracted with ethyl ether
4. dry with materialdried over MgSO4
5. concentrationconcentrated under vacuum
6. customPurification of the resultant residue on silica gel (ISCO)