Toluene → N-[2-[4-chloro-2-[6-chloro-2'-(5-fluoro-2-methylphenyl)-2,6'-dioxospiro[1H-indole-3,3'-piperidine]-4'-yl]phenoxy]-2-methylpropyl]methanesulfonamide

HRID 305980Notes

Reaction equation

HRID 305980 reaction equation
[CH2:51]1[O:52][CH2:53][CH2:54][CH2:55]1.[CH3:44][c:45]1[cH:46][cH:47][cH:48][cH:49][cH:50]1.[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:9]([cH:10]1)[NH:8][C:7](=[O:11])[C:6]21[CH:12]([c:36]2[c:37]([CH3:43])[cH:38][cH:39][c:40]([F:42])[cH:41]2)[NH:13][C:14](=[O:35])[CH2:15][CH:16]1[c:17]1[c:18]([O:24][C:25]([C:26](=[O:27])[NH:28][S:29](=[O:30])(=[O:31])[CH3:32])([CH3:33])[CH3:34])[cH:19][cH:20][c:21]([Cl:23])[cH:22]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:9]([cH:10]1)[NH:8][C:7](=[O:11])[C:6]21[CH:12]([c:36]2[c:37]([CH3:43])[cH:38][cH:39][c:40]([F:42])[cH:41]2)[NH:13][C:14](=[O:35])[CH2:15][CH:16]1[c:17]1[c:18]([O:24][C:25]([CH2:26][NH:28][S:29](=[O:30])(=[O:31])[CH3:32])([CH3:33])[CH3:34])[cH:19][cH:20][c:21]([Cl:23])[cH:22]1

Participants

4

Reactant 3

HCID 1140TolueneHCID 8028TetrahydrofuranHCID 674012216-chloro-4'-[5-chloro-2-(2-methanesulfonylamino-1,1-dimethyl-2-oxo-ethoxy)-phenyl]-2'-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

Product 1

HCID 74928774N-[2-[4-chloro-2-[6-chloro-2'-(5-fluoro-2-methylphenyl)-2,6'-dioxospiro[1H-indole-3,3'-piperidine]-4'-yl]phenoxy]-2-methylpropyl]methanesulfonamide

Sources & evidence

ORD record
ord-b5af65801bae4fa9929cfc5a170fec1e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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