反应详情

A homogeneous mixture of (5R)-5-benzyl-2,2,3-trimethyl imidazolidin-4-one dichloroaccetic acid salt (97 mg, 0.4 mmol) and N-fluorobenzenesulfonimide (3.15 g, 10 mmol) in a 9:1 mixture of acetone and isopropanol at room temperature is treated with (3-bromophenyl)acetaldehyde (280 mg, 1.4 mmol), stirred for 1 h at room temperature, cooled to −78° C., diluted with ether, and filtered through a pad of celite. The filtercake is washed with additional ether. The combined filtrates are treated with methylsulfide (5 mL), washed with saturated NaHCO3 and brine, dried over MgSO4 and concentrated under reduced pressure to give (R)-2-fluro-2-(3-bromophenyl)acetaldehyde.

1. temperaturecooled to −78° C.
2. filtrationfiltered through a pad of celite
3. washThe filtercake is washed with additional ether
4. additionThe combined filtrates are treated with methylsulfide (5 mL)
5. washwashed with saturated NaHCO3 and brine
6. dry with materialdried over MgSO4
7. concentrationconcentrated under reduced pressure