反应详情

A solution of (R)-2-fluro-2-(3-bromophenyl)-1-ethanol (5 mmol) and p-toluenesulfonyl chloride (5.1 mmol) in CH2Cl2 at ice bath temperatures is treated with stirring with pyridine. The reaction mixture is heated at reflux temperature under a nitrogen atmosphere for 16 h, cooled to room temperature, washed with 10% HCl, saturated NaHCO3 and brine, dried over MgSO4 and concentrated in vacuo to give toluene4-sulfonic acid (S)-2-(3-bromophenyl)-2-fluoro-ethyl ester.

1. temperatureThe reaction mixture is heated
2. temperatureat reflux temperature under a nitrogen atmosphere for 16 h
3. washwashed with 10% HCl, saturated NaHCO3 and brine
4. dry with materialdried over MgSO4
5. concentrationconcentrated in vacuo