反应详情

112 g (249 mM) of (2-hydroxybenzyl)triphenylphosphonium bromide, 83 g (278 mM) of nonanoic anhydride, 104 g (1.03 mM) of triethylamine and 800 ml of toluene were placed in a 3 1-three-necked flask, followed by refluxing for 4.5 hours under stirring. After the reaction, the reaction mixture was left standing at room temperature to precipitate a crystal. The crystal was removed by filtration. The filtrate was concentrated and purified by silica gel column chromatography (eluent:toluene/hexane=1/1) to obtain 44 g of liquid 2-octylbenzofuran (Yield: 76.6%).

1. temperatureby refluxing for 4.5 hours
2. customAfter the reaction
3. waitthe reaction mixture was left
4. customstanding at room temperature
5. customto precipitate a crystal
6. customThe crystal was removed by filtration
7. concentrationThe filtrate was concentrated
8. custompurified by silica gel column chromatography (eluent:toluene/hexane=1/1)