Dimethylamine → 6-[(3-chloro-4-fluoro-phenyl)methyl]-4-hydroxy-N,N,2-trimethyl-3,5-dioxo-7,8-dihydro-2,6-naphthyridine-1-carboxamide

HRID 306469Notes

Reaction equation

HRID 306469 reaction equation
[CH2:1]1[O:2][CH2:3][CH2:4][CH2:5]1.[CH3:6][NH:7][CH3:8].[Cl:36][CH2:37][Cl:38].[Cl:9][c:10]1[cH:11][c:12]([CH2:13][N:14]2[C:15](=[O:31])[c:16]3[c:17]([OH:30])[c:18](=[O:29])[n:19]([CH3:28])[c:20]([C:24]([O:26][CH3:25])=[O:27])[c:21]3[CH2:22][CH2:23]2)[cH:32][cH:33][c:34]1[F:35]>>[CH3:6][N:7]([CH3:8])[C:24]([c:20]1[n:19]([CH3:28])[c:18](=[O:29])[c:17]([OH:30])[c:16]2[c:21]1[CH2:22][CH2:23][N:14]([CH2:13][c:12]1[cH:11][c:10]([Cl:9])[c:34]([F:35])[cH:33][cH:32]1)[C:15]2=[O:31])=[O:26]

Participants

5

Reactant 4

HCID 674DimethylamineHCID 6344DichloromethaneHCID 8028TetrahydrofuranHCID 69058481HCID 69058481, compound

Product 1

HCID 546922716-[(3-chloro-4-fluoro-phenyl)methyl]-4-hydroxy-N,N,2-trimethyl-3,5-dioxo-7,8-dihydro-2,6-naphthyridine-1-carboxamide

Sources & evidence

ORD record
ord-9d3b893957064a99a13727ff2ce853b3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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