反应详情

温度

60 °C

A 2 mol/L aqueous solution of sodium hydroxide (2.14 mL) was added to a solution of ethyl [2-ethoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]acetate (0.15 g) in ethanol (10 mL), and the resulting mixture was stirred at 60° C. for 3 hrs. Water and ethyl acetate were added to the reaction mixture. The aqueous layer was separated, washed with ethyl acetate, made acidic with the addition of 2 mol/L hydrochloric acid, and extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to afford the title compound (0.066 g).

1. customThe aqueous layer was separated
2. washwashed with ethyl acetate
3. additionmade acidic with the addition of 2 mol/L hydrochloric acid
4. extractionextracted with ethyl acetate
5. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
6. customThe solvent was evaporated under reduced pressure