Hydrochloric Acid → HCID 68544108, compound

HRID 30769Notes

Reaction equation

HRID 30769 reaction equation
[OH-].[Na+].[OH:3][C@H:4]([C:32]1[CH:37]=[CH:36][C:35]([OH:38])=[CH:34][CH:33]=1)[C@@H:5]([NH:7][CH2:8][CH2:9][O:10][C:11]1[CH:16]=[C:15]([CH3:17])[C:14]([C:18]2[CH:23]=[CH:22][C:21]([O:24][CH2:25][C:26]([O:28]CC)=[O:27])=[CH:20][CH:19]=2)=[C:13]([CH3:31])[CH:12]=1)[CH3:6].O.Cl>O1CCOCC1>[OH:3][C@H:4]([C:32]1[CH:37]=[CH:36][C:35]([OH:38])=[CH:34][CH:33]=1)[C@@H:5]([NH:7][CH2:8][CH2:9][O:10][C:11]1[CH:16]=[C:15]([CH3:17])[C:14]([C:18]2[CH:23]=[CH:22][C:21]([O:24][CH2:25][C:26]([OH:28])=[O:27])=[CH:20][CH:19]=2)=[C:13]([CH3:31])[CH:12]=1)[CH3:6]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 86605509HCID 86605509, compound

Product 1

HCID 68544108HCID 68544108, compoundYield 79.5%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A 1 mol/L aqueous solution of sodium hydroxide (0.81 mL) was added to a mixture of ethyl (4′-{2-[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethylamino]ethoxy}-2′,6′-dimethyl biphenyl-4-yloxy)acetate (0.16 g), water (1 mL) and 1,4-dioxane (2 mL), and the mixture was stirred at room temperature overnight. 1 mol/L hydrochloric acid (0.81 mL) was added to the reaction mixture, and the organic solvent was evaporated under reduced pressure. The precipitate was collected by filtration to afford the title compound (0.12 g) as a pale yellow amorphous. The structure and physical data were shown in table 1.

Workup

  1. customthe organic solvent was evaporated under reduced pressure
  2. filtrationThe precipitate was collected by filtration

Sources & evidence

ORD record
ord-19f87c0c8f2e496e954cb2c4dc7b04da
Source dataset
uspto-grants-2008_09
Patent number
US07423185B2

Reaction notes

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