Tetrahydrofuran → 5-Chloro-2-(4-hydroxy-1-methylpiperidin-4-yl)benzothiophene
Reaction equation
[CH2:11]([Li:12])[CH2:13][CH2:14][CH3:15].[CH3:16][N:17]1[CH2:18][CH2:19][C:20](=[O:23])[CH2:21][CH2:22]1.[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:7][cH:8][s:9]2)[cH:10]1.[O:24]1[CH2:25][CH2:26][CH2:27][CH2:28]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:7][c:8]([C:20]3([OH:23])[CH2:19][CH2:18][N:17]([CH3:16])[CH2:22][CH2:21]3)[s:9]2)[cH:10]1Participants
5
Sources & evidence
- ORD record
- ord-7ed6d4ece7c240f5a4e05bb3dfbfb2bd
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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