Hydrochloric Acid → HCID 68547335, compound

HRID 30777Notes

Reaction equation

HRID 30777 reaction equation
[ClH:1].[OH:2][C@H:3]([C:27]1[CH:32]=[CH:31][C:30]([OH:33])=[CH:29][CH:28]=1)[C@@H:4]([NH:6][CH2:7][CH2:8][O:9][C:10]1[C:15]([CH3:16])=[CH:14][C:13]([C:17]2[CH:22]=[CH:21][C:20]([C:23]([OH:25])=[O:24])=[CH:19][CH:18]=2)=[CH:12][C:11]=1[CH3:26])[CH3:5]>O1CCOCC1.C(OCC)C>[ClH:1].[OH:2][C@H:3]([C:27]1[CH:32]=[CH:31][C:30]([OH:33])=[CH:29][CH:28]=1)[C@@H:4]([NH:6][CH2:7][CH2:8][O:9][C:10]1[C:15]([CH3:16])=[CH:14][C:13]([C:17]2[CH:22]=[CH:21][C:20]([C:23]([OH:25])=[O:24])=[CH:19][CH:18]=2)=[CH:12][C:11]=1[CH3:26])[CH3:5]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 68540748HCID 68540748, compound2×

Product 1

HCID 68547335HCID 68547335, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 312751,4-DioxaneSolvent2×

Procedure

A 4 mol/L solution of hydrogen chloride in 1,4-dioxane (0.1 mL) was added to a suspension of 4′-{2-[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethylamino]ethoxy}-3′,5′-dimethylbiphenyl-4-carboxylic acid (compound 1, 0.089 g) in 1,4-dioxane (11.0 mL), and the mixture was stirred at room temperature for 30 min. The clear solution was diluted with an excess amount of diethyl ether, and stirred at that temperature for 1 hr. The precipitate was collected by filtration to afford the title compound (0.083 g) as a gray amorphous. The structure and physical data were shown in table 4.

Workup

  1. stirringstirred at that temperature for 1 hr
  2. filtrationThe precipitate was collected by filtration

Sources & evidence

ORD record
ord-46b6dd877cdf42cd80eb313e07c87069
Source dataset
uspto-grants-2008_09
Patent number
US07423185B2

Reaction notes

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