Hydrogen Bromide → HCID 68547299, compound

Participants

Reaction Steps

To a suspension of 4′-{2-[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethylamino]ethoxy}-3′,5′-dimethyl-biphenyl-4-carboxylic acid (compound 1, 0.079 g) in 1,4-dioxane (0.91 mL) was added 47% hydrobromic acid (0.042 mL), and the mixture was stirred at room temperature for 10 min. The clear solution was diluted with an excess amount of diethyl ether, and the precipitate was collected by filtration to afford the title compound (0.037 g) as a pale brown amorphous. The structure and physical data were shown in table 4.

Provenance & Evidence