Hydrogen Bromide → HCID 68547299, compound

HRID 30779Notes

Reaction equation

HRID 30779 reaction equation
[OH:1][C@H:2]([C:26]1[CH:31]=[CH:30][C:29]([OH:32])=[CH:28][CH:27]=1)[C@@H:3]([NH:5][CH2:6][CH2:7][O:8][C:9]1[C:14]([CH3:15])=[CH:13][C:12]([C:16]2[CH:21]=[CH:20][C:19]([C:22]([OH:24])=[O:23])=[CH:18][CH:17]=2)=[CH:11][C:10]=1[CH3:25])[CH3:4].[BrH:33]>O1CCOCC1.C(OCC)C>[BrH:33].[OH:1][C@H:2]([C:26]1[CH:31]=[CH:30][C:29]([OH:32])=[CH:28][CH:27]=1)[C@@H:3]([NH:5][CH2:6][CH2:7][O:8][C:9]1[C:14]([CH3:15])=[CH:13][C:12]([C:16]2[CH:21]=[CH:20][C:19]([C:22]([OH:24])=[O:23])=[CH:18][CH:17]=2)=[CH:11][C:10]=1[CH3:25])[CH3:4]

Participants

5

Reactant 2

HCID 260Hydrogen BromideHCID 68540748HCID 68540748, compound2×

Product 1

HCID 68547299HCID 68547299, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 312751,4-DioxaneSolvent

Procedure

To a suspension of 4′-{2-[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethylamino]ethoxy}-3′,5′-dimethyl-biphenyl-4-carboxylic acid (compound 1, 0.079 g) in 1,4-dioxane (0.91 mL) was added 47% hydrobromic acid (0.042 mL), and the mixture was stirred at room temperature for 10 min. The clear solution was diluted with an excess amount of diethyl ether, and the precipitate was collected by filtration to afford the title compound (0.037 g) as a pale brown amorphous. The structure and physical data were shown in table 4.

Workup

  1. filtrationthe precipitate was collected by filtration

Sources & evidence

ORD record
ord-61b7ae0bb8ee4120b0f9e1c58b92df7b
Source dataset
uspto-grants-2008_09
Patent number
US07423185B2

Reaction notes

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