Toluene → 4,6-Dichloropyrido[3,4-d]pyrimidine

HRID 307874Notes

Reaction equation

[CH3:22][c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1.[Cl:6][c:7]1[cH:8][c:9]2[c:10]([n:11][cH:12][nH:13][c:14]2=[O:15])[cH:16][n:17]1.[O:1]=[CH:2][N:3]([CH3:4])[CH3:5].[S:18]([Cl:19])([Cl:20])=[O:21]>>[Cl:6][c:7]1[cH:8][c:9]2[c:10]([n:11][cH:12][n:13][c:14]2[Cl:20])[cH:16][n:17]1

Participants

Reactant 4

HCID 1140Toluene

HCID 6228Dimethylformamide

HCID 24386Thionyl Chloride

HCID 1354805256-chloro-3H,4H-pyrido[3,4-d]pyrimidin-4-one

Product 1

HCID 108218764,6-Dichloropyrido[3,4-d]pyrimidine

Sources & evidence

ORD record: ord-ed3cccfcd1604f89b0f1e91df33b0892
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (8/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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