Hydrochloric Acid → N-(2-fluoro-4-chloro-5-cyclopentyloxyphenyl)-3,4,5,6-tetrahydrophthalimide

HRID 307921Notes

Reaction equation

HRID 307921 reaction equation
[C:37](=[O:38])([O-:39])[O-:40].[CH3:44][C:45]#[N:46].[ClH:43].[F:17][c:18]1[c:19]([N:26]2[C:27](=[O:36])[C:28]3=[C:29]([C:30]2=[O:31])[CH2:32][CH2:33][CH2:34][CH2:35]3)[cH:20][c:21]([OH:25])[c:22]([Cl:24])[cH:23]1.[K+:41].[K+:42].[c:1]1([CH3:2])[cH:3][cH:4][c:5]([S:6]([O:7][CH:11]2[CH2:12][CH2:13][CH2:14][CH2:15]2)(=[O:8])=[O:9])[cH:10][cH:16]1>>[CH:11]1([O:25][c:21]2[cH:20][c:19]([N:26]3[C:27](=[O:36])[C:28]4=[C:29]([C:30]3=[O:31])[CH2:32][CH2:33][CH2:34][CH2:35]4)[c:18]([F:17])[cH:23][c:22]2[Cl:24])[CH2:12][CH2:13][CH2:14][CH2:15]1

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 813Potassium Cation2×HCID 6342AcetonitrileHCID 19660Carbonate IonHCID 1586511H-Isoindole-1,3(2H)-dione, 2-(4-chloro-2-fluoro-5-hydroxyphenyl)-4,5,6,7-tetrahydro-HCID 317685Cyclopentyl 4-methylbenzene-1-sulfonate

Product 1

HCID 15279390N-(2-fluoro-4-chloro-5-cyclopentyloxyphenyl)-3,4,5,6-tetrahydrophthalimide

Sources & evidence

ORD record
ord-c24893e91f804643807ff3a764909d90
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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