反应详情

4-(2-chloro-5-nitrophenyl)-3-fluoropyridine (1 eq) was stirred with Iron (0), (3 eq), in acetic acid for 10 hours at room temperature. Reaction neutralized with sodium carbonate and filtered to remove iron. Reaction partitioned between ethyl acetate and water. Organic layer separated and washed with brine, dried over sodium sulfate and concentrated to give 4-chloro-3-(3-fluoropyridin-4-yl)benzenamine. HPLC=1.72 min; MS: MH+=223.

1. customReaction
2. filtrationfiltered
3. customto remove iron
4. customReaction
5. custompartitioned between ethyl acetate and water
6. customOrganic layer separated
7. washwashed with brine
8. dry with materialdried over sodium sulfate
9. concentrationconcentrated