反应详情

N-(3-isopropylphenyl)-5-methoxybenzo[d]thiazol-2-amine was charged with hydrobromic acid (45%) and subjected to microwave at 170° C. for 10 minutes. Reaction was then neutralized with sodium carbonate (saturated solution) and partitioned between ethyl acetate and water. The organic layer was separated, washed with brine, dried over sodium sulfate and concentrated to give 2-(3-isopropylphenylamino)benzo[d]thiazol-5-ol. HPLC=4.63 min; MS: MH+=285.

1. customReaction
2. custompartitioned between ethyl acetate and water
3. customThe organic layer was separated
4. washwashed with brine
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated