反应详情

In a steel bomb were combined 4-tert-butyl aniline (1 eq) and 70% hydrogen fluoride-pyridine (25 g/gm aniline). Sodium nitrite (1.5 eq) was then added portion wise over 5 minutes. The resulting solution was allowed to stir for 1 h at room temperature and then the bomb was sealed and heated at 85° C. for 1 h. Solution was then quenched with water/ice and extracted with ethyl ether. Organics washed with brine and dried with sodium sulfate and concentrated to afford 1-tert-butyl-4-fluorobenzene.

1. customthe bomb was sealed
2. temperatureheated at 85° C. for 1 h
3. customSolution was then quenched with water/ice
4. extractionextracted with ethyl ether
5. washOrganics washed with brine
6. dry with materialdried with sodium sulfate
7. concentrationconcentrated