Toluene → 2-amino-N-(2-bromo-6-fluorophenyl)-5-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]pyridine-3-carboxamide

HRID 308925Notes

Reaction equation

HRID 308925 reaction equation
[Br:5][c:6]1[c:7]([NH2:8])[c:9]([F:13])[cH:10][cH:11][cH:12]1.[CH3:1][Al:2]([CH3:3])[CH3:4].[CH3:37][c:38]1[cH:39][cH:40][cH:41][cH:42][cH:43]1.[NH2:14][c:15]1[n:16][cH:17][c:18](-[c:25]2[cH:26][n:27][n:28]([CH:30]3[CH2:31][CH2:32][N:33]([CH3:36])[CH2:34][CH2:35]3)[cH:29]2)[cH:19][c:20]1[C:21](=[O:22])[O:23][CH3:24]>>[Br:5][c:6]1[c:7]([NH:8][C:21]([c:20]2[c:15]([NH2:14])[n:16][cH:17][c:18](-[c:25]3[cH:26][n:27][n:28]([CH:30]4[CH2:31][CH2:32][N:33]([CH3:36])[CH2:34][CH2:35]4)[cH:29]3)[cH:19]2)=[O:22])[c:9]([F:13])[cH:10][cH:11][cH:12]1

Participants

5

Reactant 4

HCID 1140TolueneHCID 27829402-Bromo-6-fluoroanilineHCID 16682925TrimethylaluminumHCID 67388477Methyl 2-amino-5-[1-(1-methyl-4-piperidyl)pyrazol-4-yl]pyridine-3-carboxylate

Product 1

HCID 673888272-amino-N-(2-bromo-6-fluorophenyl)-5-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]pyridine-3-carboxamide

Sources & evidence

ORD record
ord-f83d6346b70e4c26871e8849d29c645c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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