Dichloromethane → 2-[1-[(2-Amino-3-naphthalen-2-ylpropanoyl)amino]-2-naphthalen-2-ylethyl]-5-phenyl-1,3-thiazole-4-carboxamide

HRID 309094Notes

Reaction equation

HRID 309094 reaction equation
[C:1]([O:2][C:3](=[O:4])[NH:7][CH:8]([CH2:9][c:10]1[cH:11][c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]2[cH:18][cH:19]1)[C:20]([NH:21][CH:22]([CH2:23][c:24]1[cH:25][c:26]2[cH:27][cH:28][cH:29][cH:30][c:31]2[cH:32][cH:33]1)[c:34]1[s:35][c:36](-[c:42]2[cH:43][cH:44][cH:45][cH:46][cH:47]2)[c:37]([C:39]([NH2:40])=[O:41])[n:38]1)=[O:48])([CH3:5])([CH3:6])[CH3:49].[CH2:57]([Cl:58])[Cl:59].[OH:50][C:51]([C:52]([F:53])([F:54])[F:55])=[O:56]>>[NH2:7][CH:8]([CH2:9][c:10]1[cH:11][c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]2[cH:18][cH:19]1)[C:20]([NH:21][CH:22]([CH2:23][c:24]1[cH:25][c:26]2[cH:27][cH:28][cH:29][cH:30][c:31]2[cH:32][cH:33]1)[c:34]1[s:35][c:36](-[c:42]2[cH:43][cH:44][cH:45][cH:46][cH:47]2)[c:37]([C:39]([NH2:40])=[O:41])[n:38]1)=[O:48]

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 22949402tert-butyl N-[1-[[1-(4-carbamoyl-5-phenyl-1,3-thiazol-2-yl)-2-naphthalen-2-ylethyl]amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]carbamate

Product 1

HCID 761154232-[1-[(2-Amino-3-naphthalen-2-ylpropanoyl)amino]-2-naphthalen-2-ylethyl]-5-phenyl-1,3-thiazole-4-carboxamide

Sources & evidence

ORD record
ord-63cd72b075384f9ca2f2a50aad6d209e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

Loading…