Triphenylphosphine → 6-(2-Hydroxy-2-methylpropyl)-3-[1-[4-(6-oxo-1-propan-2-yl-3-pyridinyl)phenyl]ethyl]-6-phenyl-1,3-oxazinan-2-one

HRID 309378Notes

Reaction equation

HRID 309378 reaction equation
[Br:36][c:37]1[cH:38][cH:39][c:40](=[O:46])[n:41]([CH:43]([CH3:44])[CH3:45])[cH:42]1.[C:47](=[O:48])([O-:49])[O-:50].[CH2:53]1[O:54][CH2:55][CH2:56][O:57][CH2:58]1.[Cs+:51].[Cs+:52].[OH:1][C:2]([CH2:3][C:4]1([c:28]2[cH:29][cH:30][cH:31][cH:32][cH:33]2)[CH2:5][CH2:6][N:7]([CH:11]([CH3:12])[c:13]2[cH:14][cH:15][c:16]([B:19]3[O:20][C:21]([CH3:22])([CH3:23])[C:24]([CH3:25])([CH3:26])[O:27]3)[cH:17][cH:18]2)[C:8](=[O:10])[O:9]1)([CH3:34])[CH3:35].[Pd:59]([Cl:60])[Cl:61].[c:62]1([P:63]([c:64]2[cH:65][cH:66][cH:67][cH:68][cH:69]2)[c:70]2[cH:71][cH:72][cH:73][cH:74][cH:75]2)[cH:76][cH:77][cH:78][cH:79][cH:80]1.[c:81]1([P:82]([c:83]2[cH:84][cH:85][cH:86][cH:87][cH:88]2)[c:89]2[cH:90][cH:91][cH:92][cH:93][cH:94]2)[cH:95][cH:96][cH:97][cH:98][cH:99]1>>[OH:1][C:2]([CH2:3][C:4]1([c:28]2[cH:29][cH:30][cH:31][cH:32][cH:33]2)[CH2:5][CH2:6][N:7]([CH:11]([CH3:12])[c:13]2[cH:14][cH:15][c:16](-[c:37]3[cH:38][cH:39][c:40](=[O:46])[n:41]([CH:43]([CH3:44])[CH3:45])[cH:42]3)[cH:17][cH:18]2)[C:8](=[O:10])[O:9]1)([CH3:34])[CH3:35]

Participants

8

Reactant 7

HCID 11776Triphenylphosphine2×HCID 19660Carbonate IonHCID 24290Palladium ChlorideHCID 312751,4-DioxaneHCID 104967Cesium cation2×HCID 467388205-Bromo-1-isopropylpyridin-2(1H)-oneHCID 670197526-(2-Hydroxy-2-methylpropyl)-6-phenyl-3-[1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethyl]-1,3-oxazinan-2-one

Product 1

HCID 723444236-(2-Hydroxy-2-methylpropyl)-3-[1-[4-(6-oxo-1-propan-2-yl-3-pyridinyl)phenyl]ethyl]-6-phenyl-1,3-oxazinan-2-one

Sources & evidence

ORD record
ord-68aa9873d7e74301bebb2fa62293f9a7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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