Dimethylformamide → 4-(4-Benzylpiperazin-1-yl)-6-chloropyrimidin-2-amine

HRID 309558Notes

Reaction equation

HRID 309558 reaction equation
[C:23](=[O:24])([O-:25])[O-:26].[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1.[CH3:29][N:30]([CH3:31])[CH:32]=[O:33].[Cs+:27].[Cs+:28].[NH2:14][c:15]1[n:16][c:17]([Cl:22])[cH:18][c:19]([Cl:21])[n:20]1>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH2:10][N:11]([c:19]2[cH:18][c:17]([Cl:22])[n:16][c:15]([NH2:14])[n:20]2)[CH2:12][CH2:13]1

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 19660Carbonate IonHCID 655222-Amino-4,6-dichloropyrimidineHCID 759941-BenzylpiperazineHCID 104967Cesium cation2×

Product 1

HCID 315376104-(4-Benzylpiperazin-1-yl)-6-chloropyrimidin-2-amine

Sources & evidence

ORD record
ord-bc5fc1515d644be8ae5317d537e0cfd7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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