Dichloromethane → 1-(4-(Trifluoromethyl)phenyl)piperazine
Reaction equation
[CH2:24]([Cl:25])[Cl:26].[F:1][C:2]([c:3]1[cH:4][cH:5][c:6]([N:9]2[CH2:10][CH2:11][N:12]([C:15]([O:16][C:17]([CH3:18])([CH3:19])[CH3:20])=[O:21])[CH2:13][CH2:14]2)[cH:7][cH:8]1)([F:22])[F:23].[OH:27][C:28]([C:29]([F:30])([F:31])[F:32])=[O:33]>>[F:1][C:2]([c:3]1[cH:4][cH:5][c:6]([N:9]2[CH2:10][CH2:11][NH:12][CH2:13][CH2:14]2)[cH:7][cH:8]1)([F:22])[F:23]Participants
4
Sources & evidence
- ORD record
- ord-ff43951842134a099e00be3f03083591
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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