Dichloromethane → N-[3-[3-[2-(2,3-dihydro-1,4-benzodioxin-6-ylamino)pyrimidin-4-yl]pyrazolo[1,5-a]pyridin-2-yl]phenyl]-1-methylpyrrole-2-carboxamide

HRID 310810Notes

Reaction equation

HRID 310810 reaction equation
[C:34](=[O:35])([Cl:36])[Cl:37].[CH2:44]1[O:45][CH2:46][CH2:47][CH2:48]1.[CH3:38][n:39]1[cH:40][cH:41][cH:42][cH:43]1.[Cl:49][CH2:50][Cl:51].[NH2:1][c:2]1[cH:3][c:4](-[c:8]2[n:9][n:10]3[c:11]([cH:12][cH:13][cH:14][cH:15]3)[c:16]2-[c:17]2[n:18][c:19]([NH:23][c:24]3[cH:25][c:26]4[c:27]([cH:32][cH:33]3)[O:28][CH2:29][CH2:30][O:31]4)[n:20][cH:21][cH:22]2)[cH:5][cH:6][cH:7]1>>[NH:1]([c:2]1[cH:3][c:4](-[c:8]2[n:9][n:10]3[c:11]([cH:12][cH:13][cH:14][cH:15]3)[c:16]2-[c:17]2[n:18][c:19]([NH:23][c:24]3[cH:25][c:26]4[c:27]([cH:32][cH:33]3)[O:28][CH2:29][CH2:30][O:31]4)[n:20][cH:21][cH:22]2)[cH:5][cH:6][cH:7]1)[C:34](=[O:35])[c:40]1[n:39]([CH3:38])[cH:43][cH:42][cH:41]1

Participants

6

Reactant 5

HCID 6344DichloromethaneHCID 6371PhosgeneHCID 73041-MethylpyrroleHCID 8028TetrahydrofuranHCID 595138174-[2-(3-Aminophenyl)pyrazolo[1,5-a]pyridin-3-yl]-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-pyrimidinamine

Product 1

HCID 44529094N-[3-[3-[2-(2,3-dihydro-1,4-benzodioxin-6-ylamino)pyrimidin-4-yl]pyrazolo[1,5-a]pyridin-2-yl]phenyl]-1-methylpyrrole-2-carboxamide

Sources & evidence

ORD record
ord-5ac95035aa864b15a557105b094268e1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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