Dichloromethane → Spiro[3,1-benzoxazine-4,4'-piperidin]-2(1H)-one

HRID 311028Notes

Reaction equation

HRID 311028 reaction equation
[Cl:31][CH2:32][Cl:33].[O:1]=[C:2]1[O:3][C:4]2([c:5]3[c:6]([cH:8][cH:9][cH:10][cH:11]3)[NH:7]1)[CH2:12][CH2:13][N:14]([C:17]([O:18][C:19]([CH3:20])([CH3:21])[CH3:22])=[O:23])[CH2:15][CH2:16]2.[OH:24][C:25]([C:26]([F:27])([F:28])[F:29])=[O:30]>>[O:1]=[C:2]1[O:3][C:4]2([c:5]3[c:6]([cH:8][cH:9][cH:10][cH:11]3)[NH:7]1)[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]2

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 13050638tert-Butyl 2-oxo-1,2-dihydro-1'H-spiro[3,1-benzoxazine-4,4'-piperidine]-1'-carboxylate

Product 1

HCID 13050639Spiro[3,1-benzoxazine-4,4'-piperidin]-2(1H)-one

Sources & evidence

ORD record
ord-798ac940af4649e79a24d6fcbc73fc86
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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