Potassium Cation → 1-Tert-butyl 2-methyl 4,4-difluoro-2-[4-(5-fluoropyridin-2-yl)benzyl]pyrrolidine-1,2-dicarboxylate
Reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][C:7]2([C:21](=[O:22])[O:23][CH3:24])[N:8]([C:14](=[O:15])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[CH2:9][C:10]([F:12])([F:13])[CH2:11]2)[cH:25][cH:26]1.[Br:27][c:28]1[n:29][cH:30][c:31]([F:34])[cH:32][cH:33]1.[CH2:37]1[O:38][CH2:39][CH2:40][O:41][CH2:42]1.[F-:35].[K+:36].[Pd:119].[c:100]1([P:101]([c:102]2[cH:103][cH:104][cH:105][cH:106][cH:107]2)[c:108]2[cH:109][cH:110][cH:111][cH:112][cH:113]2)[cH:114][cH:115][cH:116][cH:117][cH:118]1.[c:43]1([P:44]([c:45]2[cH:46][cH:47][cH:48][cH:49][cH:50]2)[c:51]2[cH:52][cH:53][cH:54][cH:55][cH:56]2)[cH:57][cH:58][cH:59][cH:60][cH:61]1.[c:62]1([P:63]([c:64]2[cH:65][cH:66][cH:67][cH:68][cH:69]2)[c:70]2[cH:71][cH:72][cH:73][cH:74][cH:75]2)[cH:76][cH:77][cH:78][cH:79][cH:80]1.[c:81]1([P:82]([c:83]2[cH:84][cH:85][cH:86][cH:87][cH:88]2)[c:89]2[cH:90][cH:91][cH:92][cH:93][cH:94]2)[cH:95][cH:96][cH:97][cH:98][cH:99]1>>[c:2]1(-[c:28]2[n:29][cH:30][c:31]([F:34])[cH:32][cH:33]2)[cH:3][cH:4][c:5]([CH2:6][C:7]2([C:21](=[O:22])[O:23][CH3:24])[N:8]([C:14](=[O:15])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[CH2:9][C:10]([F:12])([F:13])[CH2:11]2)[cH:25][cH:26]1Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-ff374bf9dd1b4992afa91ecfd46074c6
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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