Hydrochloric Acid → 2-(4-{5-[2-(2-Fluoro-phenyl)-[1,8]naphthyridin-4-yl]-pyridin-3-yl}-pyrazol-1-yl)-ethanol

HRID 311611Notes

Reaction equation

HRID 311611 reaction equation
[Cl:39][CH2:40][Cl:41].[ClH:38].[F:1][c:2]1[c:3](-[c:8]2[n:9][c:10]3[n:11][cH:12][cH:13][cH:14][c:15]3[c:16](-[c:18]3[cH:19][n:20][cH:21][c:22](-[c:24]4[cH:25][n:26][n:27]([CH2:29][CH2:30][O:31][CH:32]5[CH2:33][CH2:34][CH2:35][CH2:36][O:37]5)[cH:28]4)[cH:23]3)[cH:17]2)[cH:4][cH:5][cH:6][cH:7]1.[O:42]1[CH2:43][CH2:44][O:45][CH2:46][CH2:47]1>>[F:1][c:2]1[c:3](-[c:8]2[n:9][c:10]3[n:11][cH:12][cH:13][cH:14][c:15]3[c:16](-[c:18]3[cH:19][n:20][cH:21][c:22](-[c:24]4[cH:25][n:26][n:27]([CH2:29][CH2:30][OH:31])[cH:28]4)[cH:23]3)[cH:17]2)[cH:4][cH:5][cH:6][cH:7]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 312751,4-DioxaneHCID 673805632-(2-fluoro-phenyl)-4-(5-{1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1H-pyrazol-4-yl}-pyridin-3-yl)-[1,8]naphthyridine

Product 1

HCID 673638732-(4-{5-[2-(2-Fluoro-phenyl)-[1,8]naphthyridin-4-yl]-pyridin-3-yl}-pyrazol-1-yl)-ethanol

Sources & evidence

ORD record
ord-5bad188ca5e34d69859a456a2df0c135
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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