反应详情

Malononitrile (3.303 g, 50 mmol), 2-fluorobenzaldehyde (6.205 g, 50 mmol), 1 g of molecular sieves, and 500 mg of a resin bound piperidine (described in Tetrahedron Lett., 1999, 40, 7031-33) were placed in a vessel which was irradiated in a 300 W single mode microwave for 15 seconds. The reaction mixture was taken up in iso-propyl acetate, filtered, evaporated, taken up in dichloromethane, filtered through a pad of Magnasol, evaporated, and recrystallized from ethanol to yield 2.435 g of the title material as a crystalline solid,

1. customwere placed in a vessel
2. customwhich was irradiated in a 300 W single mode microwave for 15 seconds
3. filtrationfiltered
4. customevaporated
5. filtrationfiltered through a pad of Magnasol
6. customevaporated
7. customrecrystallized from ethanol