Acetate → 6-Formyl-4-methoxy-3-(5-methyl-oxazol-2-yl)-quinoline

HRID 311657Notes

Reaction equation

HRID 311657 reaction equation
[CH2:36]([SiH:37]([CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH3:43])[CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][CH3:49])[CH2:50][CH2:51][CH2:52][CH2:53][CH3:54].[CH3:55][N:56]([CH:57]=[O:58])[CH3:59].[I:1][c:2]1[cH:3][c:4]2[c:5]([O:18][CH3:19])[c:6](-[c:12]3[o:13][c:14]([CH3:17])[cH:15][n:16]3)[cH:7][n:8][c:9]2[cH:10][cH:11]1.[O-:61][C:62]([CH3:63])=[O:64].[O-:65][C:66]([CH3:67])=[O:68].[Pd+2:60].[c:20]1([CH:21]([c:22]2[cH:23][cH:24][cH:25][cH:26][cH:27]2)[CH2:28][CH2:29][PH2:30])[cH:31][cH:32][cH:33][cH:34][cH:35]1>>[c:2]1([CH:57]=[O:58])[cH:3][c:4]2[c:5]([O:18][CH3:19])[c:6](-[c:12]3[o:13][c:14]([CH3:17])[cH:15][n:16]3)[cH:7][n:8][c:9]2[cH:10][cH:11]1

Participants

7

Reactant 6

HCID 175Acetate2×HCID 6228DimethylformamideHCID 76231CID 76231HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 53436545Diphenylpropyl phosphineHCID 585857786-Iodo-4-methoxy-3-(5-methyl-oxazol-2-yl)-quinoline

Product 1

HCID 585858616-Formyl-4-methoxy-3-(5-methyl-oxazol-2-yl)-quinoline

Sources & evidence

ORD record
ord-404887e4998b435888b066f0e98c8864
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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