Hydrochloric Acid → Hydrochloric Acid

HRID 311670Notes

Reaction equation

HRID 311670 reaction equation
[CH3:32][OH:33].[ClH:31].[F:1][c:2]1[c:3]([NH:4][c:5]2[n:6][cH:7][n:8][c:9]3[cH:10][c:11]([NH:15][C:16]([CH2:17][O:18][CH3:19])=[O:20])[cH:12][cH:13][c:14]23)[cH:21][c:22]([O:26][C:27]([O:28][CH3:29])=[O:30])[c:23]([CH3:25])[cH:24]1.[Na+:35].[OH-:34].[OH2:36]>>[ClH:31].[F:1][c:2]1[c:3]([NH:4][c:5]2[n:6][cH:7][n:8][c:9]3[cH:10][c:11]([NH:15][C:16]([CH2:17][O:18][CH3:19])=[O:20])[cH:12][cH:13][c:14]23)[cH:21][c:22]([OH:26])[c:23]([CH3:25])[cH:24]1

Participants

8

Reactant 6

HCID 313Hydrochloric AcidHCID 887MethanolHCID 923Sodium ionHCID 961HydroxideHCID 962WaterHCID 212603364-(2-Fluoro-5-methoxycarbonyloxy-4-methylanilino)-7-methoxyacetamidoquinazoline

Product 2

HCID 313Hydrochloric AcidHCID 21260317N-[4-(2-fluoro-5-hydroxy-4-methylanilino)quinazolin-7-yl]-2-methoxyacetamide

Sources & evidence

ORD record
ord-fbc22d8547d64acc9953960fd7105f6b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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