Sodium ion → tert-butyl {1-[2-(7-bromo-5-fluoro-2-oxoquinolin-1(2H)-yl)ethyl]piperidin-4-yl}carbamate

HRID 312056Notes

Reaction equation

HRID 312056 reaction equation
[Br:14][c:15]1[cH:16][c:17]([F:26])[c:18]2[cH:19][cH:20][c:21](=[O:25])[nH:22][c:23]2[cH:24]1.[Br:1][c:2]1[cH:3][c:4]([F:5])[cH:6][c:7]2[c:8]1[cH:9][cH:10][c:11](=[O:12])[nH:13]2.[CH3:29][S:30]([O:31][CH2:34][CH2:35][N:36]1[CH2:37][CH2:38][CH:39]([NH:42][C:43](=[O:44])[O:45][C:46]([CH3:47])([CH3:48])[CH3:49])[CH2:40][CH2:41]1)(=[O:32])=[O:33].[CH3:78][CH2:79][O:80][C:81](=[O:82])[CH3:83].[F:50][c:51]1[cH:52][c:53]2[c:54]([n:55][cH:56][c:57](=[O:58])[n:59]2[CH2:60][CH2:61][N:62]2[CH2:63][CH2:64][CH:65]([NH:66][C:67](=[O:68])[O:69][C:70]([CH3:71])([CH3:72])[CH3:73])[CH2:74][CH2:75]2)[cH:76][cH:77]1.[H-:27].[Na+:28]>>[Br:14][c:15]1[cH:16][c:17]([F:26])[c:18]2[cH:19][cH:20][c:21](=[O:25])[n:22]([CH2:34][CH2:35][N:36]3[CH2:37][CH2:38][CH:39]([NH:42][C:43](=[O:44])[O:45][C:46]([CH3:47])([CH3:48])[CH3:49])[CH2:40][CH2:41]3)[c:23]2[cH:24]1

Participants

8

Reactant 7

HCID 923Sodium ionHCID 8857Ethyl AcetateHCID 166653HydrideHCID 568344782-(4-((Tert-butoxycarbonyl)amino)piperidin-1-yl)ethyl methanesulfonateHCID 59397942tert-butyl{1-[2-(7-fluoro-2-oxoquinoxalin-1(2H)-yl)ethyl]piperidin-4-yl}carbamateHCID 667743297-bromo-5-fluoroquinolin-2(1H)-oneHCID 667743565-bromo-7-fluoroquinolin-2(1H)-one

Product 1

HCID 86642655tert-butyl {1-[2-(7-bromo-5-fluoro-2-oxoquinolin-1(2H)-yl)ethyl]piperidin-4-yl}carbamate

Sources & evidence

ORD record
ord-c830f382d77d4a7daa87b20c9a522937
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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