Imidazole → 3-[[tert-butyl(dimethyl)silyl]oxymethyl]-5-[4-(2,3-dihydro-1H-inden-1-ylamino)pyrrolo[2,3-d]pyrimidin-7-yl]cyclopentane-1,2-diol

HRID 312072Notes

Reaction equation

HRID 312072 reaction equation
[C:29]([CH3:30])([CH3:31])([CH3:32])[Si:33]([CH3:34])([CH3:35])[Cl:36].[CH:1]1([NH:10][c:11]2[c:12]3[c:13]([n:14][cH:15][n:16]2)[n:17]([CH:20]2[CH:21]([OH:28])[CH:22]([OH:27])[CH:23]([CH2:25][OH:26])[CH2:24]2)[cH:18][cH:19]3)[CH2:2][CH2:3][c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]21.[O:42]=[CH:43][N:44]([CH3:45])[CH3:46].[nH:37]1[cH:38][cH:39][n:40][cH:41]1>>[CH:1]1([NH:10][c:11]2[c:12]3[c:13]([n:14][cH:15][n:16]2)[n:17]([CH:20]2[CH:21]([OH:28])[CH:22]([OH:27])[CH:23]([CH2:25][O:26][Si:33]([C:29]([CH3:30])([CH3:31])[CH3:32])([CH3:34])[CH3:35])[CH2:24]2)[cH:18][cH:19]3)[CH2:2][CH2:3][c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]21

Participants

5

Reactant 4

HCID 795ImidazoleHCID 6228DimethylformamideHCID 28928tert-Butyldimethylsilyl chlorideHCID 178519745HCID 178519745, compound

Product 1

HCID 680064813-[[tert-butyl(dimethyl)silyl]oxymethyl]-5-[4-(2,3-dihydro-1H-inden-1-ylamino)pyrrolo[2,3-d]pyrimidin-7-yl]cyclopentane-1,2-diol

Sources & evidence

ORD record
ord-9c9915e9556d4fc192af9ae6f974c7c6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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