Toluene → 2-(3,5-Difluorophenyl)-5,5-dimethylpiperidine
Reaction equation
[CH2:2]([Al+:3][CH2:4][CH:5]([CH3:6])[CH3:7])[CH:8]([CH3:9])[CH3:10].[CH2:35]1[O:36][CH2:37][CH2:38][CH2:39]1.[CH3:28][c:29]1[cH:30][cH:31][cH:32][cH:33][cH:34]1.[F:11][c:12]1[cH:13][c:14]([CH:19]2[CH2:20][CH2:21][C:22]([CH3:26])([CH3:27])[C:23](=[O:25])[NH:24]2)[cH:15][c:16]([F:18])[cH:17]1.[H-:1]>>[F:11][c:12]1[cH:13][c:14]([CH:19]2[CH2:20][CH2:21][C:22]([CH3:26])([CH3:27])[CH2:23][NH:24]2)[cH:15][c:16]([F:18])[cH:17]1Participants
6
Sources & evidence
- ORD record
- ord-9dffd2de4908485c8bb6b1d1867763f5
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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